Platelet Rich Fibrin ( PRF )
Platelet rich fibrin (PRF) is a by-product of blood (plasma) that is rich in platelets. New technology permits doctors to harvest and produce a sufficient quantity of platelets from blood, which is drawn from the patient while they are having outpatient surgery.
Why All The Excitement About PRF?
PRF permits the body to take advantage of the normal healing pathways at a greatly accelerated rate. During the healing process, the body rushes many cells and cell-types to the wound in order to initiate the healing process. One of those cell types is platelets. Platelets perform many functions, including formation of a blood clot and release of growth factors (GF) into the wound. These growth factors; platelet derived growth factors (PDGF), transforming growth factor beta (TGF), and insulin-like growth factor (ILGF), function to assist the body in repairing itself by stimulating stem cells to regenerate new tissue. The more growth factors released and sequestered into the wound, the more stem cells are stimulated to produce new tissue. Thus, PRP permits the body to heal faster and more efficiently.
A subfamily of TGF, is bone morphogenic protein (BMP). BMP has been shown to induce the formation of new bone in research studies in both animals and humans. This is of great significance to the surgeon who places dental implants. By adding PRP, and BMP, to the implant site with bone substitute particles, the implant surgeon can now grow bone more predictably and faster than ever before.
PRF Has Many Clinical Applications
PRF can be used to aid Bone grafting for dental implants. This includes onlay and inlay grafts, sinus lift procedures, ridge augmentation procedures, closure of cleft and/or lip, and palate defects. It can also assist in repair of bone defects created by removal of teeth, or small cysts and repair of fistulas between the sinus cavity and mouth.
PRF Also Has Many Advantages
Safety: PRF is a by-product of the patient’s own blood, therefore, disease transmission is not an issue.
Convenience: PRF can be generated in the office while the patient is undergoing an outpatient surgical procedure.
Faster healing: The supersaturation of the wound with PRF, and thus growth factors, produces an increase of tissue synthesis and faster tissue regeneration.
Frequently Asked Questions About PRF
Is PRF safe? Yes. During the outpatient surgical procedure a small amount of your own blood is drawn out via the IV. This blood is then placed in the PRF centrifuge machine .